Other
m-Phenylenediamine and its salts
Safety score · 0–100
Avoid
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
M-Phenylenediamine and its salts is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.
m-Phenylenediamine (m-PDA) carries an extensive hazard profile including H301 (toxic if swallowed), H311 (toxic in contact with skin), H317 (skin sensitizer), H319 (causes serious eye irritation), H331 (toxic if inhaled), H341 (suspected mutagen), H400/H410 (aquatic toxicity), and multiple other hazard statements. It is classified as a Category 1 acute toxicant and mutagen, and is listed in EU Regulation 1223/2009 Annex II (the list of substances prohibited in cosmetic products). The compound is a potent skin and respiratory sensitizer that can cause severe allergic reactions, and its aromatic amine structure is associated with sensitization and potential carcinogenicity in hair dye applications.
Known concerns
- Banned in EU cosmetics — Annex II
- Category 1 acute toxicity (oral, dermal, inhalation)
- Skin and respiratory sensitizer
- Mutagen (H341)
- Severe aquatic toxicity
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related others
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.