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Hair dye intermediate family

m-Phenylenediamine and its salts

CAS 108-45-2
15

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

This entry covers m-phenylenediamine and its salts as a prohibited family in EU cosmetics. They are not permitted in finished products due to sensitization, mutagenicity, and carcinogenicity concerns.

Skin benefits

  • Historically used as oxidative hair dye intermediate family
  • Various salts improved solubility in formulations
  • Produced dark shades when oxidized

Known concerns

  • Family of compounds prohibited in EU cosmetics under Annex II
  • Strong skin sensitizers and suspected mutagens
  • Cross-reactivity with PPD and related dyes
  • Not permitted in finished cosmetic products

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.