M-PHENYLENEDIAMINE SULFATE

Colorant

5

Avoid

CAS Number: 541-70-8

About M-PHENYLENEDIAMINE SULFATE

The sulfate salt of m-phenylenediamine. Same prohibition as the parent diamine — banned in EU cosmetics and clinically linked to hair-dye allergy.

Detailed Analysis

m-Phenylenediamine sulfate (CAS 541-70-8) is the sulfate salt of m-phenylenediamine and is covered by the same EU Cosmetics Regulation Annex II entry — the prohibition applies to the diamine and its salts. It is a recognised cross-reactor with PPD-class hair-dye allergens and carried the same in-vitro genotoxicity signals that led to the parent compound being removed from the permitted hair-dye list. There is no legitimate cosmetic use pathway.

Skin Benefits

  • Historical hair-dye use only

Known Concerns

  • EU Annex II prohibited (salt form covered by parent entry)
  • PPD cross-reactivity
  • Genotoxicity signals
  • Contact sensitizer

Safety Score

5

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.