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Antioxidant

MACELIGNAN

CAS 107534-93-0
65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A nutmeg-derived lignan studied for brightening and antioxidant effects. Promising but cosmetic data is thin.

Macelignan (CAS 107534-93-0) is a lignan isolated from Myristica fragrans (nutmeg). In vitro it shows antioxidant, anti-tyrosinase and anti-inflammatory activity, with some interest as a natural skin-brightening actives ingredient. No CIR monograph exists and it is not individually listed in EU CosIng with restrictions. Human dermal safety data is limited; typical cosmetic inclusion is low (0.01-0.1%). Like many bioactive phytochemicals, tolerability depends on purity and vehicle.

Function

ANTIMICROBIAL, ANTIOXIDANT, DEODORANT, ORAL CARE

Skin benefits

  • Nutmeg-derived lignan with antioxidant and anti-inflammatory activity in vitro
  • Documented anti-tyrosinase activity (potential skin-brightening)
  • Natural phytochemical, active at low concentrations

Known concerns

  • Limited cosmetic-specific human safety data
  • Potency of biological activity may translate to irritation in some users
  • Regulatory/CIR status unclear

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.