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MANGANESE TRIPEPTIDE-1

CAS -
72

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A synthetic tripeptide (glycyl-histidyl-lysine) chelated with manganese, promoted for collagen-boosting and skin-firming benefits. The peptide portion is widely used in anti-aging cosmetics, though manganese requires careful concentration control.

Manganese Tripeptide-1 is a chelate complex of the tripeptide Glycyl-Histidyl-Lysine with manganese. The peptide sequence is identical to the copper-binding motif of human procollagen, and the complex is used in anti-aging cosmetics for its purported collagen-stimulating effects. The ingredient is not listed in EU Annex II (banned substances) of the Cosmetics Regulation. However, excessive free manganese can contribute to neurotoxicity, and the safety of the manganese-peptide complex depends on controlled release and concentration.

Skin benefits

  • Promotes collagen synthesis
  • Skin-firming and anti-aging properties
  • May help reduce appearance of fine lines

Known concerns

  • Manganese at high concentrations may contribute to neurotoxicity
  • The peptide chelation may affect manganese bioavailability
  • Limited long-term safety data for topical use

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.