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Skin Conditioning

MATRINE

CAS 519-02-8 Updated
45

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Matrine — a Sophora root alkaloid with anti-inflammatory and antimicrobial activity. Pharmacologically active rather than a benign botanical; limited cosmetic safety data argues for moderate caution.

Skin benefits

  • Sophora root-derived alkaloid with anti-inflammatory activity
  • Studied for itch and irritation relief
  • Antimicrobial activity in vitro

Known concerns

  • Plant alkaloid with pharmacological activity; not a benign botanical
  • Limited cosmetic CIR/SCCS dossier
  • Systemic toxicity at oral high doses raises caution for cosmetic levels
  • Use with awareness, particularly in leave-on products

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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ASIVATREP
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.