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Prohibited pharmaceutical (Annex II)

Mefeclorazine (INN) and its salts

CAS 1243-33-0
5

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A piperazine medicinal substance banned from cosmetics under EU Annex II. Pharmaceutical agents like this carry systemic risks and are not appropriate for topical use in beauty products.

Skin benefits

  • Pharmacological activity studied historically as a piperazine derivative
  • Of interest only in regulated medicinal contexts

Known concerns

  • Prohibited substance under EU Cosmetics Regulation Annex II
  • Pharmaceutical with systemic effects not suitable for topical cosmetic use
  • No demonstrated safe cosmetic application

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.