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Banned / Annex II

MERCURIC OXIDE

CAS 21908-53-2
2

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A mercury compound — banned in EU cosmetics (Annex II). Neurotoxic, nephrotoxic, and environmentally persistent. Never use.

Mercuric Oxide (HgO, CAS 21908-53-2) is an inorganic mercury(II) compound. Mercury and ALL its compounds are listed in EU Cosmetics Regulation 1223/2009 Annex II (substances prohibited in cosmetic products) with only narrowly defined exceptions for eye-area preservatives that phase out globally. Mercury is a well-characterized neurotoxin (CNS damage), nephrotoxin (kidney injury), and reproductive toxicant; percutaneous absorption from topical mercury-containing creams has caused severe systemic mercury poisoning, documented in numerous case reports of skin-lightening product misuse. FDA, Health Canada, EU SCCS and WHO all classify mercury compounds as inappropriate for cosmetic use. Environmental persistence and bioaccumulation compound the concern. There is no safe cosmetic use scenario.

Function

ANTIMICROBIAL

Skin benefits

  • None

Known concerns

  • EU Annex II banned substance
  • Systemic mercury poisoning via skin
  • Neurotoxicity and nephrotoxicity
  • Severe environmental impact

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Related banned / annex iis

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.