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Methadone hydrochloride

CAS 1095-90-5
8

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Methadone Hydrochloride is a cosmetic ingredient. Exercise caution due to limited available safety data.

Methadone is a synthetic opioid agonist with high abuse potential and severe acute toxicity. It carries H300 (fatal if swallowed), H311/H331 (toxic in contact with skin/by inhalation), H317 (skin sensitization), H334 (respiratory sensitization), H341 (suspected mutagen), and H361 (reproductive toxicity) statements. As a Schedule II controlled substance and narcotic analgesic, methadone is absolutely prohibited in cosmetic products under EU Regulation 1223/2009 Annex II.

Known concerns

  • Schedule II controlled narcotic
  • Acute opioid toxicity (H300/H311/H331)
  • CMR Category 2 substance (H341/H361)
  • Severe abuse potential
  • EU Annex II prohibition

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.