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Skin Conditioning

METHIONYL S-MELITTIN SP

35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A synthetic copy of melittin, the main toxin in bee venom, with a methionine added. Cytolytic at higher levels and capable of triggering allergic reactions in bee-allergic users — real concerns for cosmetic use.

Function

SKIN PROTECTING

Skin benefits

  • Synthetic analogue avoids direct bee venom sourcing
  • Studied for anti-inflammatory and antimicrobial effects
  • Used at very low concentrations in finished products

Known concerns

  • Melittin is a pore-forming, cytolytic peptide
  • Potential for skin irritation and allergic sensitization
  • Bee venom allergens cross-react in sensitive users
  • Limited cosmetic safety dossier

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.