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Skin Conditioning

METHOTREXOYL OLIGOPEPTIDE-59

35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A peptide conjugated with a methotrexate-derived group. Methotrexate is a chemotherapy antimetabolite; cosmetic use of such derivatives is poorly justified and lacks independent safety data — avoid.

Function

SKIN CONDITIONING

Skin benefits

  • Used at trace levels in formulation
  • Marketed for targeted skin signaling

Known concerns

  • Methotrexoyl moiety derives from methotrexate, an antimetabolite chemotherapy drug
  • Cosmetic use of cytotoxic-drug derivatives is questionable from a regulatory standpoint
  • Independent safety data is essentially absent
  • Not appropriate for at-home cosmetic use without rigorous proof of inertness

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.