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Prohibited solvent

METHOXYDIGLYCOL

CAS 111-77-3
28

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Diethylene glycol monomethyl ether, an industrial solvent classified as a reproductive toxin and prohibited from EU cosmetic products. Readily absorbed through skin and metabolised to toxic methoxyacetic acid.

Function

FRAGRANCE, SOLVENT, VISCOSITY CONTROLLING, PERFUMING

Skin benefits

  • Effective solvent for resins, dyes and difficult-to-dissolve actives
  • Coupling agent in mixed-solvent systems

Known concerns

  • Diethylene glycol monomethyl ether (DEGME) is a known reproductive toxin
  • EU Cosmetics Regulation Annex II includes DEGME as prohibited substance in cosmetics
  • Classified as Reproductive toxicity category 1B under EU CLP
  • Readily absorbed through skin
  • Metabolises to toxic methoxyacetic acid

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Related prohibited solvents

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.