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METHOXYTRIMETHYLPHENYL DIHYDROXYPHENYL PROPANOL

62

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A synthetic resveratrol-like antioxidant with a trimethoxyphenyl core — designed to deliver free radical neutralization with improved skin penetration compared to natural polyphenol antioxidants.

Methoxytrimethylphenyl Dihydroxyphenyl Propanol is a synthetic phenol composed of a 3,4,5-trimethoxyphenyl ring system connected to a dihydroxyphenyl (catechol) moiety through a three-carbon propanol chain. The trimethoxy substitution on the A-ring increases lipophilicity and skin penetration relative to natural flavonoids. The catechol B-ring provides the antioxidant pharmacophore — the ortho-dihydroxy configuration efficiently donates electrons to neutralize reactive oxygen species while forming a stable semiquinone radical. The propanol linker provides conformational flexibility and may support receptor-mediated activity. This compound class is structurally related to resveratrol and piceid but with enhanced stability and different pharmacokinetic properties.

Function

ANTIOXIDANT, SKIN CONDITIONING

Skin benefits

  • Potent free radical scavenging antioxidant
  • Improved skin penetration vs. natural polyphenol antioxidants
  • May inhibit melanin synthesis via tyrosinase modulation
  • Stable under daylight exposure compared to resveratrol

Known concerns

  • Synthetic compound with limited long-term topical safety data
  • May be a skin sensitizer in susceptible individuals due to catechol oxidation potential
  • The trimethoxyphenyl group may affect endocrine pathways at high exposure

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.