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Preservative

METHYLISOTHIAZOLINONE

CAS 2682-20-4 Updated
22

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A preservative that triggered a major contact-allergy epidemic. EU banned it from leave-on cosmetics in 2017; rinse-off use is now capped at 0.0015%.

Function

PRESERVATIVE

Skin benefits

  • Effective broad-spectrum preservative at low %
  • Active against gram-negative bacteria

Known concerns

  • Potent skin sensitizer
  • EU banned in leave-on products since 2017
  • Restricted to 0.0015% in rinse-off
  • One of top contact allergens of the decade

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

PC

PubChem

U.S. NIH compound data, GHS hazard codes and toxicity literature.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.