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Skin Conditioning

METHYLSULFINYLBUTYL PIPERIDINECARBOTHIOAMIDE

CAS 1350914-98-5
55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A specialty synthetic with a sulforaphane-related sulfoxide motif and a piperidine thioamide. Novel, unreviewed — caution warranted.

Methylsulfinylbutyl Piperidinecarbothioamide (CAS 1350914-98-5) is a small synthetic molecule combining a methylsulfinylbutyl side chain (the pharmacophore of sulforaphane, an isothiocyanate/sulfoxide derived from broccoli) with a piperidine thioamide group. Thioamides are classically bioactive — they are the core structure of thyroid-inhibitor drugs (methimazole, propylthiouracil), which raises concern about off-target pharmacological activity even at cosmetic exposure. The sulfoxide motif is reactive. No CIR or SCCS review. Public safety and efficacy data in cosmetics is essentially absent outside supplier materials. Default-cautious scoring strongly applies.

Function

BLEACHING

Skin benefits

  • Specialty cosmetic active — possibly positioned for pigmentation or redness claims
  • Contains sulfoxide (sulforaphane-like) motif

Known concerns

  • Thioamide functional group — potent enzyme inhibitor class (thyroid)
  • Sulfoxide chemistry — reactive metabolism potential
  • No CIR or SCCS review
  • Limited public safety data
  • Novel and uncharacterized in cosmetic literature
  • Default-cautious scoring warranted

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.