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Skin Conditioning

METHYLTHIOADENOSINE

CAS 2457-80-9
80

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

An endogenous nucleoside metabolite of methionine pathways — anti-inflammatory signalling, gentle on skin. Emerging but promising conditioner.

Methylthioadenosine (MTA, CAS 2457-80-9) is a naturally occurring sulfur-containing nucleoside, a key intermediate in polyamine biosynthesis. Published preclinical and early clinical work describes anti-inflammatory and immunomodulatory effects via adenosine-receptor signalling. In cosmetics it functions as a skin-conditioning agent. No CIR monograph yet; no EU CosIng restriction. Because it is an endogenous metabolite, intrinsic toxicity is low; cosmetic dossiers are still emerging and supplier purity matters for stability.

Function

SKIN CONDITIONING

Skin benefits

  • Endogenous nucleoside metabolite
  • Anti-inflammatory signalling activity
  • Well tolerated in topical studies
  • Supports skin conditioning

Known concerns

  • Limited large-scale cosmetic clinical data
  • Supplier-dependent stability
  • No CIR monograph yet

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.