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Skin Conditioning

MYRISTOYL TETRAPEPTIDE-46

70

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A tetrapeptide anchored to myristic acid (a 14-carbon fatty acid) for improved skin delivery. Part of the broader lipidated-peptide family.

Myristoyl tetrapeptide-46 is a 4-residue synthetic peptide acylated with myristic acid (C14 saturated fatty acid), a close cousin of palmitoylated peptides. The lipid tail aids partitioning into the stratum corneum lipid matrix. Short peptides are non-sensitizing and readily biodegradable, and myristic acid is a natural fatty acid with a well-characterised cosmetic safety record. The specific conjugate has not been reviewed by CIR or SCCS, and published efficacy data is largely supplier-derived. Typical use levels are in the low ppm range in leave-on formulations.

Function

SKIN CONDITIONING

Skin benefits

  • Lipid tail boosts skin affinity
  • Low irritation
  • Compatible with emulsion systems

Known concerns

  • Supplier-based efficacy data
  • No regulatory monograph
  • Possible concern for acne-prone users at high levels

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.