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N-HYALURONOYL 5-HYDROXYDOPAMINE

38

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A tyrosine-hydroxide-inspired conjugate that may influence melanin synthesis, restricted in EU cosmetic applications.

N-Hyaluronoyl 5-Hydroxydopamine is a hybrid molecule combining a hyaluronic acid fragment with a dopamine derivative, designed to modulate melanogenesis. It is listed under EU CosIng restriction II/21, indicating it is permitted only under strictly defined conditions in cosmetic products. The 5-hydroxydopamine moiety raises concerns regarding potential cytotoxicity to melanocytes at high concentrations.

Skin benefits

  • May inhibit excessive melanin production for brightening effect
  • Antioxidant properties from the dopamine moiety

Known concerns

  • EU CosIng restriction II/21 — permitted only under strict concentration limits
  • Potential melanocytotoxicity from the hydroxydopamine moiety
  • Insufficient long-term safety data for unrestricted cosmetic use

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.