N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE

Other

27

Avoid

CAS Number: 54381-16-7

About N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE

An oxidative hair dye intermediate with acute toxicity, sensitisation, and environmental hazard classifications, restricted in the EU under Annex III reference III/198.

Detailed Analysis

This p-phenylenediamine derivative carries severe EU hazard classifications: H301 (acute toxicity swallow), H311 (acute toxicity skin), H315, H317, H319 (irritation and sensitisation), H331 (acute toxicity inhalation), and environmental hazards H400, H410, H411. It is listed in EU Annex III reference III/198, indicating it is permitted only under specific conditions of use and concentration in oxidative hair dye formulations. It must never be used in eyelash or eyebrow products.

Skin Benefits

  • ✓ Used as a primary intermediate in oxidative hair dyeing processes
  • ✓ Contributes to long-lasting permanent hair colour development

Known Concerns

  • ⚠ Acute toxicity hazard via multiple routes (H301, H311, H331)
  • ⚠ Known skin sensitiser (H317) — risk of allergic contact dermatitis
  • ⚠ Eye irritant (H319) and skin irritant (H315)
  • ⚠ Very toxic to aquatic organisms (H400, H410)
  • ⚠ EU Annex III restricted — specific conditions apply; prohibited for eyebrows/eyelashes

Safety Score

27

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.