N,N,N',N'-Tetramethyl-4,4'-methylenedianiline

Other

8

Avoid

CAS Number: 101-61-1

About N,N,N',N'-Tetramethyl-4,4'-methylenedianiline

N,N,N',N'-Tetramethyl-4,4'-methylenedianiline is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Detailed Analysis

N,N,N',N'-Tetramethyl-4,4'-methylenedianiline (CAS 101-61-1) is classified as a Category 1B carcinogen (H350) under EU CLP regulation, meaning it is presumed to cause cancer in humans. It is listed on EU Annex II (the list of substances prohibited in cosmetic products) as a confirmed prohibited carcinogen. Beyond carcinogenicity, it exhibits acute aquatic toxicity (H400, H410) and specific organ toxicity (H373). The benzidine-derived structure means it is also a suspected mutagen. Its presence in any cosmetic ingredient at any concentration is illegal in the European Union.

Known Concerns

  • ⚠ EU Annex II prohibited — confirmed carcinogen (H350)
  • ⚠ Suspected mutagen (H341)
  • ⚠ Reproductive toxicity suspected (H351)
  • ⚠ Acute aquatic toxicity (H400, H410)
  • ⚠ Specific organ toxicity (H373)

Safety Score

8

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.