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N-NICOTINOYL PHYTOSPHINGOSINE

83

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

N-Nicotinoyl Phytosphingosine is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

N-Nicotinoyl Phytosphingosine is an amide of niacin (nicotinic acid/vitamin B3) and phytosphingosine, a long-chain base found in skin ceramides. This conjugate merges the brightening and barrier-supporting properties of niacinamide with the ceramide-mimicking structure of phytosphingosine. EU CosIng lists no Annex II or III restrictions for this material. Phytosphingosine derivatives are widely used in skincare for their anti-inflammatory and microbiome-balancing properties.

Skin benefits

  • Barrier strengthening via ceramide-analog mechanism
  • Brightening and tone-evening from niacin component
  • Anti-inflammatory and skin microbiome balancing
  • Antimicrobial activity against acne-related organisms

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.