Other
N-NICOTINOYL TYRAMINE
Safety score · 0–100
Avoid
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A nicotinic acid derivative explicitly prohibited in EU cosmetic products under Annex II restriction II/21 due to sensitization and photosensitization potential.
N-Nicotinoyl Tyramine (CAS 71106-22-2 based on structure; PubChem CID 3043417) is an amide of nicotinic acid and tyramine. It is listed in EU Annex II under restriction II/21, which prohibits its use in cosmetic products. The restriction likely relates to its potential for skin sensitization, photosensitization, or metabolic conversion to bioactive nicotinic acid derivatives that may cause cutaneous flushing or allergic reactions. The tyramine moiety also raises concerns about tyramine interactions and vasopressor effects if absorbed systemically. As a restricted Annex II substance, it cannot be used in any cosmetic formulation marketed in the EU at any concentration.
Known concerns
- EU Annex II restricted — explicitly prohibited in cosmetic products
- Skin sensitization and photosensitization potential
- Potential vasopressor effects from tyramine moiety
- Metabolic conversion to bioactive nicotinic acid derivatives
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.