Other
1-(2-Amino-5-chlorophenyl)-2,2,2-trifluoro-1,1-ethanediol, hydrochloride
Safety score · 0–100
Avoid
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A halogenated aromatic compound with a trifluoroethanol functionality, carrying corrosive, aquatic toxic, and suspected carcinogenic hazard classifications that make it unsuitable for cosmetic use.
This chloro- and fluoro-substituted aromatic ethanediol is a highly hazardous compound with a H302 (harmful if swallowed), H314 (skin corrosion), H411 (aquatic chronic toxicity), and H350 (suspected carcinogen) hazard profile. The trifluoroethanol and 2-amino-5-chlorophenyl combination is unusual in cosmetics and raises significant concern. In the EU, substances classified as carcinogenic category 1B (H350) are prohibited from cosmetic products under Annex II of Regulation (EC) No 1223/2009. The hydrochloride salt form enhances dermal absorption, increasing systemic exposure risk.
Known concerns
- Suspected carcinogen H350 (EU Annex II prohibited)
- Corrosive H314
- Aquatic chronic toxicity H411
- Enhanced dermal absorption (hydrochloride salt)
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related others
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.