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2,2'-METHYLENEBIS-4-AMINOPHENOL HCL

CAS 27311-52-0
18

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

2,2'-methylenebis-4-aminophenol Hcl is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

This HCl salt of 2,2'-Methylenebis-4-aminophenol carries a 'Danger' signal word with multiple severe hazard classifications: H300 (acute toxicity if swallowed), H319 (serious eye damage), H372 (specific target organ toxicity — repeated exposure), and H400/H410 (acute aquatic toxicity). The aromatic diamine structure is a known sensitiser and poses risks of respiratory sensitisation. Its unsuitability for cosmetic use is reflected in its severe hazard profile, and it would require explicit EU approval if used at all — which appears unlikely given these signals.

Known concerns

  • ACUTE TOXICITY if swallowed (H300)
  • Serious eye damage (H319)
  • Specific target organ toxicity — repeated exposure (H372)
  • Acute aquatic toxicity (H400)
  • Chronic aquatic hazard (H410)
  • 'DANGER' signal word — highest hazard classification

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.