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Naphazoline (INN) and its salts

CAS 835-31-4
28

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Naphazoline (inn) And Its Salts is a cosmetic ingredient. Exercise caution due to limited available safety data.

Naphazoline is an imidazoline derivative with potent alpha-adrenergic vasoconstrictor activity, used topically in ophthalmic products to reduce redness. It is classified as a pharmaceutical substance and is not permitted in cosmetic products under EU Cosmetics Regulation 1223/2009. Repeated use can cause rebound rhinitis and systemic absorption raises cardiovascular concerns. CAS 835-31-4 refers to the base compound.

Known concerns

  • Prohibited in cosmetic products
  • Cardiovascular effects with systemic absorption
  • Rebound redness with prolonged use
  • Not approved as cosmetic ingredient in EU

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.