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NIACINAMIDOETHYL RETINOATE

CAS 1642294-93-6
45

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A hybrid retinol-vitamin B3 molecule designed to deliver anti-aging retinoid benefits with reduced irritation compared to pure retinol.

Niacinamidoethyl Retinoate is a hybrid molecule combining a niacinamide (vitamin B3) moiety with a retinoate ester, designed to reduce the skin irritation associated with retinoids while delivering anti-aging benefits. Retinoids are subject to EU restrictions in cosmetics (Annex III/3 — vitamin A compounds restricted at certain concentrations due to teratogenicity concern), and the specific compound would need to be evaluated under this framework. The hybrid approach may reduce but not eliminate retinoid concerns.

Skin benefits

  • Anti-aging — retinoid activity
  • Reduced irritation vs pure retinol
  • Vitamin B3 (niacinamide) skin benefits

Known concerns

  • EU Annex III/3 — vitamin A restriction may apply
  • Retinoid activity concern — potential irritation
  • Pregnancy/teratogenicity concern if absorbed systemically

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.