Skip to content

NIACINAMIDOETHYL TRIPHENYLPHOSPHONIUMPENTAMIDE CHLORIDE

CAS 3002023-68-6
75

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A vitamin B3 (niacinamide) derivative linked to a triphenylphosphonium moiety, designed to deliver niacinamide's skin benefits deeper into the skin with enhanced mitochondrial targeting.

Niacinamidoethyl Triphenylphosphoniumpentamide Chloride is an organic salt combining niacinamide (vitamin B3) with a triphenylphosphonium cation via a pentamidoethyl linker. The triphenylphosphonium group confers lipophilicity and mitochondrial accumulation. This ingredient is designed to leverage the well-established benefits of niacinamide (anti-inflammatory, barrier support, evening of skin tone) while the phosphonium moiety may enhance cellular uptake and mitochondrial targeting.

Skin benefits

  • Antioxidant protection
  • Skin barrier support
  • Even skin tone
  • Anti-inflammatory properties
  • Enhanced cellular delivery via mitochondrial targeting

Known concerns

  • May cause mild flushing at high concentrations
  • Rare contact allergy reported

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Check your shelf

Find NIACINAMIDOETHYL TRIPHENYLPHOSPHONIUMPENTAMIDE CHLORIDE in your products.

Scan any cosmetic product with LuxSense to see if it contains NIACINAMIDOETHYL TRIPHENYLPHOSPHONIUMPENTAMIDE CHLORIDE and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.