Skin Conditioning
NICOTINOYL HEXAPEPTIDE-56
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A niacin (B3)-linked synthetic hexapeptide intended to combine niacinamide-like tone benefits with peptide signaling.
Nicotinoyl hexapeptide-56 is a synthetic hexapeptide with a nicotinic acid (niacin) group conjugated to it. The design intent is a dual-action molecule combining the hypothesized peptide signaling with niacin's established brightening/anti-inflammatory profile. Manufacturing is solid-phase peptide synthesis, producing a structurally defined molecule. Topical peptides generally have low systemic absorption through intact skin. Efficacy data is primarily supplier-generated in-vitro or small clinical panels. No CIR or SCCS review.
Function
Skin benefits
- Niacin-conjugated synthetic peptide — dual niacinamide and peptide signaling potential
- Claimed skin-tone support
- Synthetic manufacture gives defined structure
Known concerns
- Limited independent clinical evidence — efficacy mostly supplier data
- No published CIR/SCCS opinion
- Limited long-term safety data
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.