Skin Conditioning
NICOTINOYL OCTAPEPTIDE-9
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
An eight-amino-acid peptide conjugated with niacin (vitamin B3). Pairs peptide signaling with niacinamide-like effects; generally well tolerated.
Nicotinoyl octapeptide-9 is a synthetic octapeptide functionalized with a nicotinoyl (vitamin B3 / niacin) group. The design aims to combine peptide signaling activity with the well-established brightening and barrier-supporting effects of niacinamide derivatives. Nicotinic acid esters can cause transient skin flushing through prostaglandin release, though conjugation typically moderates this. No SCCS or CIR opinion specific to this peptide exists. Generally used at low parts-per-million levels in serums. No GHS hazard classification applies at cosmetic use concentrations.
Function
Skin benefits
- Niacin-conjugated peptide combining two skin-conditioning motifs
- Supplier data suggests brightening and barrier support
- Low use levels limit exposure risk
Known concerns
- Proprietary ingredient without independent regulatory dossier
- Nicotinoyl moiety may cause transient flushing in sensitive users
- Efficacy claims primarily supplier-generated
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.