Preservative
NISIN
Safety score · 0–100
Good
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A small natural antimicrobial peptide (E234) produced by Lactococcus lactis — used as a food preservative for decades and now as a cosmetic preservative. Excellent safety record, mostly active against Gram-positive bacteria.
Skin benefits
- Natural broad-spectrum antimicrobial peptide
- Particularly active vs Gram-positive bacteria
- Food-grade and GRAS safety status (E234)
- Effective at low concentrations
Known concerns
- Limited activity against Gram-negative bacteria and fungi
- Possible immune-stimulation in sensitised individuals
- Activity drops at pH > 7
- Dairy-fermentation origin — allergen carry-over possible
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related preservatives
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.