Skin Conditioning
NONAPEPTIDE-49
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A synthetic nine-amino-acid peptide used as a skin-conditioning agent. Designer nonapeptide with limited public safety/efficacy literature.
Nonapeptide-49 is a nine-residue synthetic peptide developed for cosmetic skin-conditioning use. Like most modern designer nonapeptides it is supplied dilute and dosed at parts-per-million levels in serums and creams. The class is generally considered low-irritation due to poor stratum corneum penetration; very large peptides are non-bioavailable on intact skin. No independent CIR or SCCS review of this specific INCI is available; efficacy claims rely on supplier studies. Listed in EU CosIng. Conservative tier: yellow with low evidence.
Function
Skin benefits
- Trace-level skin conditioning
- Low sensitization potential
- Compatible with most water-based formats
Known concerns
- Limited independent safety data
- No CIR/SCCS monograph
- Supplier-driven efficacy claims
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.