Skip to content

NONOXYNOL-1

CAS 26027-38-3 (generic)/ 37205-87-1 (generic)/ 27986-36-3
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A short-chain ethoxylated alkylphenol surfactant with known sensitisation potential, requiring careful use in cosmetic formulations.

Nonoxynol-1 (CAS 26027-38-3) is an ethoxylated nonylphenol (NPE) surfactant with a low degree of ethoxylation (1 mole EO). Short-chain nonoxynols and NPEs have been subject to regulatory scrutiny in the EU due to concerns about ecotoxicity (they are endocrine-disrupting to aquatic organisms) and potential contamination with 4-nonylphenol, a substance of concern. While Nonoxynol-1 itself is not specifically listed in EU Annex II or III, higher nonoxynols (Nonoxynol-9, -10) have been reviewed for potential reproductive effects. The substance should be used with caution.

Skin benefits

  • Surfactant and emulsifying function

Known concerns

  • Aquatic ecotoxicity and endocrine disruption potential
  • Potential contamination with 4-nonylphenol
  • Skin sensitisation reported with alkylphenol surfactants

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Check your shelf

Find NONOXYNOL-1 in your products.

Scan any cosmetic product with LuxSense to see if it contains NONOXYNOL-1 and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.