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NONOXYNOL-1

CAS 26027-38-3 (generic)/ 37205-87-1 (generic)/ 27986-36-3
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A short-chain ethoxylated alkylphenol surfactant with known sensitisation potential, requiring careful use in cosmetic formulations.

Nonoxynol-1 (CAS 26027-38-3) is an ethoxylated nonylphenol (NPE) surfactant with a low degree of ethoxylation (1 mole EO). Short-chain nonoxynols and NPEs have been subject to regulatory scrutiny in the EU due to concerns about ecotoxicity (they are endocrine-disrupting to aquatic organisms) and potential contamination with 4-nonylphenol, a substance of concern. While Nonoxynol-1 itself is not specifically listed in EU Annex II or III, higher nonoxynols (Nonoxynol-9, -10) have been reviewed for potential reproductive effects. The substance should be used with caution.

Skin benefits

  • Surfactant and emulsifying function

Known concerns

  • Aquatic ecotoxicity and endocrine disruption potential
  • Potential contamination with 4-nonylphenol
  • Skin sensitisation reported with alkylphenol surfactants

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.