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NOOTKATONE

CAS 4674-50-4
75

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A grapefruit-derived sesquiterpene ketone used as fragrance and natural insect repellent with good safety profile.

Nootkatone is a sesquiterpene ketone extracted from grapefruit (Citrus paradisi) responsible for its characteristic scent. It is also a naturally occurring insect repellent with IFRA-approved safe use levels. The PubChem CID 1268142 profile indicates generally low toxicity, though it may cause mild irritation at high concentrations.

Skin benefits

  • Natural insect repellent
  • Fragrance enrichment
  • Antioxidant properties

Known concerns

  • Mild skin irritation at high concentrations
  • Citrus-derived allergen possible
  • Photosensitization concern (furanocoumarin co-extraction)

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.