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Norfenefrine hydrochloride

CAS 4779-94-6
28

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Norfenefrine Hydrochloride is a cosmetic ingredient. Exercise caution due to limited available safety data.

Norfenefrine is a phenylethanolamine derivative with selective alpha-1 adrenergic agonist activity used as a vasoconstrictor and mydriatic. It carries H302 (harmful if swallowed). As a sympathomimetic drug with cardiovascular effects, it is regulated as a pharmaceutical substance in the EU. Cosmetic use of alpha-adrenergic agonists is limited and subject to specific SCCS assessment.

Known concerns

  • Alpha-adrenergic agonist
  • Oral acute toxicity (H302)
  • Pharmaceutical substance
  • Cardiovascular effects

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.