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o-Phenylenediamine and its salts

CAS 95-54-5
15

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

O-Phenylenediamine and its salts is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

o-Phenylenediamine and its salts are specifically listed in EU Annex III of Regulation 1223/2009 for restricted use in oxidative hair dye products. The extensive hazard profile includes H350 (carcinogenicity), H341 (mutagenicity), H317 (skin sensitization), and multiple acute toxicity statements (H301, H312, H332). The salt forms facilitate dermal absorption and may increase the bioavailability of the parent aromatic amine, compounding safety concerns.

Known concerns

  • EU Annex III restricted CMR substance
  • H350 carcinogenicity
  • H341 mutagenicity
  • H317 skin sensitization
  • Multiple acute toxicity hazards

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.