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Banned toxic glycoside

Oleandrin

CAS 465-16-7
2

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Oleandrin is a potent cardiac glycoside toxin from oleander, banned from cosmetics in the EU. It has no legitimate skincare use, and any contact poses serious cardiac and systemic toxicity risk.

Skin benefits

  • No legitimate cosmetic benefit
  • Studied only in oncology research, never as a topical ingredient

Known concerns

  • Highly toxic cardiac glycoside from Nerium oleander
  • Prohibited in cosmetics under EU Annex II
  • Lethal at small oral doses, dermal absorption can be clinically significant
  • No safe topical use established

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.