Oleandrin
Safety score · 0–100
Avoid
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
Oleandrin is a cosmetic ingredient. Raw material has significant toxicity. Exercise caution due to limited available safety data.
Oleandrin is a potent cardiac glycoside that inhibits the sodium-potassium ATPase pump, causing life-threatening arrhythmias at low doses. The H300 (fatal if swallowed) and H330 (fatal if inhaled) classifications confirm extreme acute toxicity. Oleander extracts are sometimes promoted in alternative medicine but are never permitted in EU-regulated cosmetic products due to the narrow margin between pharmacologically active and toxic doses.
Known concerns
- H300/H330: fatal acute toxicity by ingestion and inhalation
- Cardiac glycoside: narrow therapeutic index
- No safe cosmetic use; strongly prohibited
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.