P-CRESOL
Other
Caution
CAS Number: 106-44-5
About P-CRESOL
P-Cresol is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.
Detailed Analysis
p-Cresol (4-methylphenol) is a methyl-substituted phenol that presents significant toxicological concerns due to its ability to penetrate skin and cause systemic toxicity. Like other cresols, p-cresol acts as a protoplasmic poison affecting the central nervous system and can cause liver and kidney damage at sufficient exposure levels. The compound is listed in EU cosmetic contaminant guidance at low maximum residue limits due to concerns about presence as an impurity in phenolic or aromatic cosmetic ingredients. The methylphenol structure contributes to lipophilicity that enhances skin penetration compared to simpler phenols, raising concerns for cosmetic safety especially in leave-on products.
Known Concerns
- ⚠ Significant skin absorption and systemic toxicity
- ⚠ Neurotoxicity concern at elevated exposure
- ⚠ Hepatotoxicity and nephrotoxicity potential
- ⚠ EU cosmetic contaminant restriction applies
Safety Score
Caution
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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Download LuxSenseThis information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.