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P-CRESYL OCTANOATE

CAS 59558-23-5
74

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

P-Cresyl Octanoate is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

p-Cresyl octanoate (4-methylphenyl octanoate) is an ester formed from p-cresol and octanoic acid, functioning primarily as a fragrance ingredient with floral-waxy character. Esterification of the phenolic hydroxyl group substantially reduces the toxicological concerns associated with free phenols, including skin absorption, systemic toxicity, and irritation potential. EU Regulation 1223/2009 does not list this compound in restricted or prohibited annexes, indicating acceptable safety at current usage levels. The octanoate ester is metabolized differently than free cresol, reducing concerns about phenol-related toxicity. The compound is considered safe for use in cosmetic fragrances within normal concentration ranges, though standard allergen labeling considerations apply if derived from sensitizing natural sources.

Skin benefits

  • Fragrance with pleasant floral-waxy character
  • Esterification reduces phenolic toxicity concerns

Known concerns

  • Minor skin sensitization potential depending on source
  • Standard fragrance allergen considerations may apply
  • Esters of cresol raise minor concerns if hydrolysis occurs in use

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Related others

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.