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Colorant

P-PHENYLENEDIAMINE

CAS 106-50-3
14

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

PPD — a powerful hair dye precursor and one of the most documented contact allergens in cosmetics. EU sharply restricts its use; banned for eyebrow and eyelash dyes.

Skin benefits

  • Permanent hair-dye coupler
  • Produces wide range of dye shades
  • Effective at very low concentrations

Known concerns

  • GHS acute toxicity Cat 3 (oral, dermal, inhalation)
  • Strong skin sensitizer (EU Cat 1A)
  • Severe allergic contact dermatitis
  • EU strictly restricted: max 2% in oxidative hair dyes, banned for eyebrow/eyelash dyes
  • IARC Group 3 with persistent allergy concerns

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.