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P-TERT-BUTYL-ALPHA-METHYLHYDROCINNAMAL /METHYLANTHRANILATE SCHIFF BASE

CAS 91-51-0
38

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A Schiff base fragrance compound combining a modified cinnamal with methyl anthranilate, carrying warnings for skin sensitization and reproductive toxicity.

This Schiff base fragrance is formed by the condensation of p-tert-butyl-alpha-methylhydrocinnamal (a modified cinnamal derivative) with methyl anthranilate. It carries hazard statements H317 (may cause allergic skin reaction), H361 (suspected of damaging fertility or the unborn child), and H412 (harmful to aquatic life with long-lasting effects). Fragrance materials with H317 and H361 classifications are under increasing regulatory scrutiny in the EU, with the SCCS evaluating their safety for cosmetic use. The Schiff base structure may undergo hydrolysis, releasing the individual components including methyl anthranilate, which itself is a fragrance allergen.

Skin benefits

  • Fragrance material providing aromatic properties

Known concerns

  • H317 – may cause allergic skin reaction (skin sensitizer)
  • H361 – suspected reproductive toxicity
  • H412 – harmful to aquatic life with long-lasting effects
  • May hydrolyze to release fragrance allergens

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.