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Anti-aging signal peptide

PALMITOYL PENTAPEPTIDE-5

CAS -
78

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Palmitoyl pentapeptide-5 is a collagen-stimulating signal peptide used in anti-aging products. It is well tolerated and class-analogous to Matrixyl peptides, though clinical evidence remains modest.

Skin benefits

  • Lipopeptide signaling matrikine for skin
  • Stimulates collagen and extracellular matrix synthesis
  • Anti-aging support with smoother skin texture
  • Palmitoyl tail aids skin penetration
  • Well tolerated in cosmetic formulations

Known concerns

  • Efficacy in finished products often modest
  • Stability requires careful formulation pH
  • Limited independent clinical evidence
  • Cost and supplier variability
  • Possible mild irritation in sensitive users

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.