Conditioning Agent
PALMITOYL SH-NONAPEPTIDE-15 ALANINE SP AMIDE
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A lipophilic hair-conditioning peptide modified with palmitic acid and an amide terminus, designed to deposit at the hair surface for shine, smoothness, and damage repair benefits.
This ingredient is the product of reacting palmitic acid with a synthetic peptide consisting of sh-Nonapeptide-15 and Alanine, where the C-terminus is amidated. The palmitoylation provides affinity for the hair shaft (which is rich in keratin-associated proteins and surface lipids), enabling substantive deposition from rinse-off and leave-in hair-care formulations. The EU cosmetics regulation does not restrict palmitoylated nonapeptides or C-terminal amides in hair-care applications. Palmitic acid is a common cosmetic ingredient; the sh-Nonapeptide-15 sequence (based on human Interleukin-8 fragment) has no safety restrictions in the EU. The amide terminus is a standard, chemically stable peptide modification.
Function
Skin benefits
- Palmitic acid modification enables substantive binding to hair keratin for lasting conditioning effects
- Nonapeptide component may contribute to scalp skin-conditioning benefits
- C-terminal amide enhances chemical stability and resistance to enzymatic degradation
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.