Conditioning Agent
PALMITOYL TETRAPEPTIDE-132 SH-PENTAPEPTIDE-40 AMIDE
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A dual-peptide complex lipidated with palmitic acid and amidated at the C-terminus, designed for skin-conditioning and anti-aging applications with enhanced dermal delivery.
This ingredient results from the reaction of palmitic acid with a synthetic peptide combining Tetrapeptide-132 and sh-Pentapeptide-40, with the C-terminus present as an amide. Tetrapeptide-132 is commonly associated with matrikine-like signals involved in extracellular matrix maintenance; sh-Pentapeptide-40 is a recombinant human sequence. Palmitoylation enhances the molecule's ability to interact with and cross the skin's lipid matrix. The EU cosmetics regulation does not restrict this combination of peptides. The amide terminus is a standard stabilizing modification. Palmitic acid and human-sequence peptides are individually recognized as safe cosmetic ingredients; their combination in a lipopeptide format is consistent with established cosmetic ingredient technology.
Function
Skin benefits
- Tetrapeptide-132 component may support collagen and elastin maintenance for anti-aging benefits
- Palmitoylation enables superior skin penetration and retention vs. non-lipidated peptide versions
- Dual-peptide design provides multiple skin-conditioning mechanisms in a single ingredient
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.