Skin Conditioning
PALMITOYL TRIPEPTIDE-100
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A palmitic-acid-conjugated tripeptide for skin conditioning. Lipidation improves skin penetration; independent safety data is limited.
Palmitoyl Tripeptide-100 is a tripeptide N-terminally conjugated to a palmitic acid (C16) chain, formulated for cosmetic skin-conditioning use. The palmitoyl moiety improves stratum corneum penetration relative to unmodified peptides — the same Matrixyl-style strategy used in many designer peptide actives. Used at parts-per-million levels in serums and creams. No independent CIR or SCCS review of this specific INCI is available; efficacy claims rely on supplier studies. The class as a whole has a long market history with low irritation reports. Listed in EU CosIng. Conservative tier: yellow with low evidence.
Function
Skin benefits
- Lipidation improves skin uptake
- Trace-level skin conditioning
- Compatible with most leave-on formulas
Known concerns
- Limited independent safety data
- No CIR/SCCS monograph
- Slightly higher penetration than unmodified peptides
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related skin conditionings
Check your shelf
Find PALMITOYL TRIPEPTIDE-100 in your products.
Scan any cosmetic product with LuxSense to see if it contains PALMITOYL TRIPEPTIDE-100 and get a full ingredient breakdown with safety scores.
This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.