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Skin Conditioning

PARTHENOLIDE

CAS 20554-84-1
30

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Parthenolide — the active sesquiterpene lactone in feverfew (Tanacetum parthenium). A strong contact allergen; the EU recommends feverfew extracts in cosmetics be parthenolide-depleted.

Function

SKIN CONDITIONING

Skin benefits

  • Anti-inflammatory in vitro
  • Bioactive sesquiterpene

Known concerns

  • Strong contact allergen
  • Sesquiterpene-lactone sensitiser (T.R.U.E. test)
  • EU/IFRA require parthenolide-free feverfew
  • Atopic skin contraindication

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.