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Endogenous lipid amide

PEA PALMITATE

72

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Palmitoylethanolamide is a lipid amide with soothing and barrier-supportive properties used in sensitive-skin care. Tolerability is good but topical efficacy data remain moderate at best.

Skin benefits

  • Palmitoylethanolamide (PEA) is studied for anti-inflammatory and skin-soothing activity
  • Modulates mast cell activity and may calm irritated or itchy skin
  • Lipid character supports skin barrier compatibility
  • Generally well tolerated in topical formulations

Known concerns

  • Topical efficacy data are limited and largely from small clinical studies
  • Stability and bioavailability in finished products can vary
  • Naming overlap with pea (Pisum sativum) palmitate can cause confusion and allergen concerns

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.