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Skin Conditioning

PEGANUM HARMALA SEED EXTRACT

Updated
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Seed extract of Syrian rue, naturally rich in MAOI alkaloids (harmine, harmaline). These are pharmacologically active drugs — cosmetic use is questionable and not appropriate as a leave-on ingredient.

Function

HAIR CONDITIONING

Skin benefits

  • Traditional dye and folk-medicine plant
  • Harmaline alkaloids with reported antioxidant activity

Known concerns

  • Peganum harmala seeds contain harmine and harmaline — beta-carboline alkaloids that are potent monoamine oxidase inhibitors (MAOIs)
  • Pharmacologically active, with documented neurotoxicity in oral exposure
  • Cosmetic appropriateness questionable; topical absorption can deliver bioactive doses
  • Not generally recognized as safe for cosmetic use
  • Not on EU cosmetics positive lists

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.