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Prohibited alkaloid

Pelletierine and its salts

CAS 2858-66-4 / 4396-01-4
8

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A pomegranate-bark alkaloid that is explicitly prohibited in EU cosmetics under Annex II. It has no legitimate place in skincare and any detection signals a serious quality control failure.

Skin benefits

  • Historical use as a veterinary anthelmintic (deworming) agent
  • Naturally occurring alkaloid in pomegranate root bark

Known concerns

  • Listed on EU Cosmetic Regulation Annex II of substances prohibited in cosmetics
  • Pharmacologically active alkaloid with neurotoxic potential
  • No legitimate use in finished cosmetic products
  • Any presence above trace contamination is a regulatory violation

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.