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PENTAMETHYL-SPIROBICYCLOHEPTANE-DIOXANE

CAS 121251-67-0
42

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

PENTAMETHYL-SPIROBICYCLOHEPTANE-DIOXANE is a cosmetic ingredient used in product formulation. Exercise caution due to limited available safety data.

Pentamethyl-spirobicycloheptane-dioxane (CAS 121251-67-0) is a spirocyclic fragrance combining a spiro-bicycloheptane skeleton with a dioxane ring and five methyl substituents. The GHS hazard profile includes H315 (causes skin irritation), H319 (causes serious eye irritation), and H411 (toxic to aquatic life with long-lasting effects). The dioxane ring is a chemically stable heterocycle, but the high degree of substitution may affect biodegradability. Under EU Regulation (EC) No 1223/2009, no specific cosmetic restrictions apply, but the compound's irritation and environmental hazard profile necessitate careful formulation management and adherence to IFRA guidelines.

Skin benefits

  • Fragrance functionality

Known concerns

  • H315 skin irritation
  • H319 eye irritation
  • H411 aquatic environmental hazard
  • Low biodegradability due to high substitution

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.