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Skin Conditioning

PENTAPEPTIDE-18

CAS - Updated
72

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A small signal peptide (Leuphasyl) marketed to soften expression lines. Generally low-risk on skin; efficacy claims rely mostly on supplier studies.

Skin benefits

  • Signal peptide marketed for expression-line softening
  • Used in eye and skin treatments
  • Low irritation at typical %

Known concerns

  • Limited independent peer-reviewed efficacy data
  • Marketing claims outpace evidence
  • Cost-driven low in-use concentrations

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.