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PENTAPEPTIDE-2

CAS -
82

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A synthetic pentapeptide containing arginine, glycine, isoleucine, serine, and tyrosine, used in anti-aging skin care for its potential collagen-stimulating effects.

Pentapeptide-2 is a synthetic pentapeptide containing five specific amino acids (arginine, glycine, isoleucine, serine, and tyrosine) functioning as a skin-conditioning agent. It is designed to mimic or stimulate the activity of naturally occurring peptides involved in skin matrix maintenance. Like other cosmetic peptides, it is not listed in EU Annexes II or III and has a favorable safety profile. The small molecular size limits penetration beyond the superficial skin layers, and the defined amino acid sequence avoids concerns about unexpected biological activity. SCCS has not identified concerns with peptide use in cosmetics at typical use concentrations.

Skin benefits

  • Potential to stimulate collagen and elastin production
  • Skin-conditioning and firming benefits
  • May reduce appearance of fine lines and wrinkles

Known concerns

  • Generally very safe; rare allergic reactions possible
  • Quality control important for peptide identity and purity

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.